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KMID : 0882420210960060463
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Korean Journal of Medicine
2021 Volume.96 No. 6 p.463 ~ p.477
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Appropriate Use of Glycopeptide Antibiotics and Therapeutic Drug Monitoring for Invasive Infections
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Kim Si-Ho
Lee Soo-Youn
Kang Cheol-In
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Abstract
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Vancomycin and teicoplanin are representative glycopeptide antibiotics with activities against gram-positive cocci. The area under the drug concentration?time curve (AUC)/minimal inhibitory concentration (MIC) has been extensively used as an indicator of the bacteriological response to glycopeptide antibiotics, and the trough concentration has been used as a surrogate marker for the AUC/MIC. However, the guidelines for therapeutic drug monitoring (TDM) are being revised in accordance with increasing pharmacokinetic understanding of glycopeptide antibiotics. This review describes the pharmacokinetic/pharmacodynamic characteristics of glycopeptide antibiotics and discusses their optimal use with appropriate TDM.
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KEYWORD
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Vancomycin, Teicoplanin, Glycopeptides, Drug monitoring, Dose-response relationship, drug
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